Always be at full health to survive falling into the void.
Shift+right-click a chest to pick it up.
Always read the the quest descriptions as only things that need them have them.
Put a block above your Snowman, so that the rain doesn't kill him.
Make a Compression Dynamo to generate power from your extra Creosote Oil.
Turn all your regular Furnaces into Inferium Furnaces to make them more efficient.
Put all your giant setups in Compact Machines to save space.
Both the efficiency and the speed of your condenser matter, so try to even them out.
Grind Leaves to get more food.
Make sure to automate just about everything.
Don't delete your Archaic Bricks. You can use them for UU-Matter later on.
When creating an island, make sure that you're in a good biome.
Use a Forestry Worktable to switch between conflicting recipes.
Press "X" to switch between inventory rows.
Press "Backspace" to go to the previous recipe in JEI.
Make Snad or Red Snad to grow Cacti and Sugar Canes 2 times faster.
Make Soul Snad to grow Nether Warts 4 times faster.
Make better Watering Cans and larger farms to grow more crops faster.
Use the Lava you already have to make more Lava faster.
Once you have an AA Crusher, in normal mode, you can make Sugar from Rice.
Multiply the numbers in JEI to see how much alchemical dust a 100/100 condenser uses.
The yield is how much the purple bar is filled, not a chance.
Make a Sand generator with Lava and Liquid Starlight.
Craft an Extractor to get more Rubber from your Sap.
You gain a heart for every 50 different foods you eat overall.